Clinical management of women at high risk of breast cancer

Abstract

PURPOSE OF REVIEW: This article reviews the evidence that underpins breast cancer screening and prevention strategies for women at high risk of the disease, with a particular focus on evidence published in the last 18 months. The review is timely because the US National Comprehensive Cancer Network, the UK National Institute for Health and Care Excellence and the American Society of Clinical Oncology have recently updated relevant guidelines that inform practice. RECENT FINDINGS: In the recently published literature, there have been several important findings. A meta-Analysis of randomized trials of selective oestrogen receptor modulators (SERMs), along with the first results from the Intern..